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KMID : 0385019970130020161
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Korean Journal of Laboratory Animal Science
1997 Volume.13 No. 2 p.161 ~ p.165
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The Anticryptosporidial Effects of Sulfadimethoxine, Toltrazuril and the Extracts of Herbs for Cryptosporidium parvum isolated from Mouse in Korea
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Abstract
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To evaluate the anticryptosporidial effects of sulfadimethoxine, toltrazuril and the extracts of two lands of herbs, Atemisia(A) annua and Amaranthus(A) magostanus, we infected the 6×10⁴ oocyste of isolate of Crytosporidium(C) parvum from mouse in Korea per mouse immunosuppressed with prednisolone and treated with some drugs. Cryptosporidial parasites in the intestinal tissue were investigated at 7 days after infection.
The reduction of the median number of cryptosporidial developmental stages per ileac tissue section for sulfadimethoxine ranged from 50.7 to 83.7% and for toltrazuril ranged from 53.7 to 87.0%. When sulfadimethoxine and toltrazuril were administrated together, they had synergistic effects. A annua was effective in reducing the severity of cryptosporidial infection, but A mangostanus was not. The reduction of the median number of cryptosporidial developmental stages per ileac tissue section for A annua ranged from 81.6 to 83.2%.
The results suggest that some components of A annua can be developed with anticryptosporidial drug.
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